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Can MDMA Play a Role in the Treatment of Substance Abuse?Current Drug Abuse Reviews - 2013

MDMA Verslaving

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#1 Phlogiston



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Posted 01 October 2013 - 04:03 PM



Can MDMA Play a Role in the Treatment of Substance Abuse?

A wider array of treatments are needed for people with substance abuse disorders. Some psychedelic compounds have been assessed as potential substance abuse treatments with promising results. MDMA may also help treat substance abuse based on shared features with psychedelic compounds and recent reports indicating that MDMAassisted psychotherapy can reduce symptoms of PTSD. Narrative reports and data from early investigations found that some people reduced or eliminated their substance use after receiving MDMA, especially in a therapeutic setting. MDMA is a potent monoamine releaser with sympathomimetic effects that may indirectly activate 5-HT2A receptors. It increases interpersonal closeness and prosocial feelings, potentially through oxytocin release. Findings suggest that ecstasy, material represented as containing MDMA, is associated with deleterious long-term effects after heavy lifetime use, including fewer serotonin transporter sites and impaired verbal memory. Animal and human studies demonstrate moderate abuse liability for MDMA, and this effect may be of most concern to those treating substance abuse disorders. However, subjects who received MDMA-assisted psychotherapy in two recent clinical studies were not motivated to seek out ecstasy, and tested negative in random drug tests during follow-up in one study. MDMA could either directly treat neuropharmacological abnormalities associated with addiction, or it could indirectly assist with the therapeutic process or reduce symptoms of comorbid psychiatric conditions, providing a greater opportunity to address problematic substance use. Studies directly testing MDMA-assisted psychotherapy in people with active substance abuse disorder may be warranted.



Dit was nieuw voor mij.

Drugs against War

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#2 snaap



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Posted 07 October 2013 - 10:26 PM

In de abstract staat voor mij alleen niet echt iets nieuws. Nieuwe ingang voor 't gebruik van MDMA, en een redelijk voor de hand liggende. In diezelfde issue staan nog meer interessante artikelen trouwens. Enne, watch for an OPEN special issue in 2014 in datzelfde journal... ;)

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#3 2_muffins


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Posted 08 October 2013 - 09:27 PM

voor zover ik kan opmaken uit de abstract gaat het hier om mensen die in eerste instantie behandeld werden met ptst en vervolgens als bijeffect minder drugs gingen gebruiken.


op basis daarvan vraag ik me af of het wel echt ingezet kan worden als middel voor het tegengaan van middelen misbruik. mogelijk dat het onderliggende problemen kan oplossen en dat cliënten die drugs misbruiken om te copen met hun trauma/problemen er als bi-effect baat bij kunnen hebben, maar ik zie niet hoe ze hieruit echt een middel hebben gevonden wat drugs misbruik helpt voorkomen. 


heeft iemand het volledige artikel?

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#4 Phlogiston



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Posted 08 October 2013 - 09:58 PM


Drugs against War

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