Here we'll try to keep a list of combinations of drugs that aren't safe to take in combination. This will be a work in progress & this list will not be exhaustive, so please still research things thoroughly before you ingest them!
If your combination is not in the list, or you would like to ask about a specific combination or discuss potentially dangerous/risky combinations, or even make suggestions for this thread, please visit the Dangerous Combination Discussion Thread.
It would also be wise to check out the Medication & Supplement Interaction Thread for further information on medication reactions beyond simply stating whether a combination is dangerous or not.
If you see anything wrong in this list or something that needs to be added, please either post in the above thread, or PM one of the PD moderators and we'll get right on it.
Table of Contents
You can use the find/search function (Ctrl + F) to search for any of the sections mentioned in the contents and quickly find dangerous combinations for these drugs.
Known Dangerous Combinations
MAOIs
SSRI/SNRI antidepressants
Anticonvulsants
Beta-blockers
Triptans
5-HTP
Alcohol
Ibogaine
Serotonin releasers
Stimulants
Potentially/Likely Dangerous Combinations
Serotonin releasers
Stimulants
Known Dangerous Combinations
MAOIs (e.g. Phenelzine, Tranylcypramine, Selegiline):
X All phenthylamine psychedelics (e.g. DOx, 2C-x, 3C-x, TMA-x, 25x-NBOMe)
X aMT (alpha-Methyltryptamine)
X MDxx (e.g. MDMA, MDA, MDEA)
X Other serotonin releasers (e.g. 6-APB, 5-APB, 5-API, 5-IAI, MDAI)
X All cathinones
X DXM (Dextromethorphan)
X Ibogaine
X SSRI/SNRI antidepressants (e.g. Sertraline, Seroxat)
X Methoxetamine
X Tramadol
X 5-HTP
SSRI/SNRI antidepressants (e.g. Sertraline, Seroxat):
X aMT (alpha-Methyltryptamine)
X 2C-T-7
X Ayahuasca/Pharmahuasca
X Other MAOIs (e.g. Phenelzine, Selegiline)
X DXM (Dextromethorphan)
X Ibogaine
X Tramadol
X 5-HTP
Anticonvulsants (e.g. Lithium, Valproate):
X All tryptamines
X All phenethylamines
X Ibogaine
Beta-blockers (e.g. Propranolol, Atenolol):
X All stimulants and empathogens (e.g. Amphetamine, Cocaine, MDMA, Mephedrone)
X aMT (alpha-Methyltryptamine)
X LSD/LSA
X Datura/Belladonna/Brugmansia
Triptans (e.g. Sumatriptan, Rizatriptan, Zolmitriptan):
X aMT
X 2C-T-7
X Ayahuasca/Pharmahuasca
X Other MAOIs (e.g. Phenelzine, Selegiline)
X LSD/LSA
5-HTP:
X aMT (alpha-Methyltryptamine)
X 2C-T-7
X Ayahuasca/Pharmahuasca
X Other MAOIs (e.g. Phenelzine, Selegiline)
X All SSRIs/SNRIs (e.g. Sertraline, Seroxat)
X MDxx (e.g. MDMA, MDA, MDEA)
X Other serotonin releasers (e.g. 6-APB, 5-APB, 5-API, 5-IAI, MDAI)
Alcohol (e.g. Beer, Wine, Vodka):
X Ibogaine
Additionally, tyramine-containing alcoholic beverages such as draught beer and wine should not be combined with any of the following:
X aMT
X Ayahuasca/Pharmahuasca
X 2C-T-7
X Other MAOIs (e.g. Phenelzine, Selegiline)
Ibogaine:
X Alcohol
X DXM
X All SSRIs/SNRIs (e.g. Sertraline, Seroxat)
X MDxx (e.g. MDMA, MDA, MDEA)
X Other serotonin releasers (e.g. 6-APB, 5-APB, 5-API, 5-IAI, MDAI)
X All other stimulants (e.g. Amphetamine, Cocaine, MDPV)
X All anticonvulsants (e.g. Lithium, Valproate)
X Antibiotics
X Grapefruit Juice
X Quinine (Tonic water)
Serotonin releasers (e.g. MDMA, MDA, MDEA, 6-APB, 5-APB, MDAI, Mephedrone, Methylone):
X aMT (alpha-Methyltryptamine)
X 2C-T-7
X Ayahuasca/Pharmahuasca
X Other MAOIs (e.g. Phenelzine, Selegiline)
X DXM (Dextromethorphan)
X Ibogaine
X 5-HTP
Stimulants (e.g. Amphetamine, Cocaine, MDPV, Methcathinone):
X Beta-blockers
X Ibogaine
Potentially/Likely Dangerous Combinations
Serotonin releasers (e.g. MDMA, MDA, MDEA, 6-APB, 5-APB, MDAI, Mephedrone, Methylone):
X 5-MeO-MiPT and 5-MeO-DiPT
X Methoxetamine
Stimulants (e.g. Amphetamine, Cocaine, MDPV, Methcathinone):
X All of the NBOMe series (e.g. 25C-NBOMe, 25I-NBOMe)
X 5-MeO-MiPT and 5-MeO-DiPT
X Bromo-DragonFLY
X aMT (alpha-Methyltryptamine)
X 2C-T-7
X Ayahuasca/Pharmahuasca
X Other MAOIs (e.g. Phenelzine, Selegiline)
Alcohol (e.g. Beer, Wine, Vodka):
X Dissociatives (e.g. Ketamine, DXM, PCP, Methoxetamine)
