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Smoking Linked To Brain Damagetabak

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#1 mind



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Posted 25 June 2009 - 02:14 AM

Smoking Linked To Brain Damage
ScienceDaily (June 23, 2009) —

New research which suggests a direct link between smoking and brain damage will be published in the July issue of the Journal of Neurochemistry. Researchers, led by Debapriya Ghosh and Dr Anirban Basu from the Indian National Brain Research Center (NBRC), have found that a compound in tobacco provokes white blood cells in the central nervous system to attack healthy cells, leading to severe neurological damage.

The research centers on a compound known as NNK, which is common in tobacco. NNK is a procarinogen, a chemical substance which becomes carcinogenic when it is altered by the metabolic process of the body.

Unlike alcohol or drug abuse NNK does not appear to harm brain cells directly, however, the research team believe it may cause neuroinflamation, a condition which leads to disorders such as Multiple Sclerosis.

"Considering the extreme economical and disease burden of neuroinflammation related disorders, it is extremely important from a medical, social and economic point of view to discover if NNK in tobacco causes neuroinflammation" said Ghosh.

To prove if such a link exists the team conducted two types of tests, one outside of a living host in glass and one in laboratory mice. The team used blot analysis techniques which showed that the introduction of NNK resulted in a clear increase in proinflammatory signaling proteins, proinflammatory effector proteins and other stress related proteins. Increased levels of proinflammatory cytokines, which act as molecular messengers between cells, were also detected.

This shows that NNK provokes an exaggerated response from the brain's immune cells, known as microglia. Microglia cells act as 'destroyers' for the brain by attacking damaged or unhealthy cells. However, when provoked by NNK these cells start to attack healthy brain cells rather than the unhealthy cells they are supposed to attack.

"Our findings prove that tobacco compound NNK can activate microglia significantly which subsequently harms the nerve cells," said Basu.

While other harmful side effects of smoking, such as lung disease, usually derive from tar or smoke this research suggests damage is not confined only to smoking. NNK is present in all forms of tobacco and therefore it can also enter the body through chewing.

The study also suggests that second hand smoking may lead to the same neuroinflamation conditions. Concentrations of NNK in tobacco can vary from 20-310 nanograms in cigarettes. However, NNK is also present in the smoke itself, meaning that smoke-filled air indoors may contain up to 26 nanograms of NNK. This means that both direct and second-hand smoking can lead to substantial measures of NNK intake.

"This research sheds light on the processes that lead to nerve cell damage in those who smoke cigarettes or consume tobacco products on regular basis," said Ghosh.


Edited by mind, 25 June 2009 - 02:14 AM.

Letterlijk, spreekwoordelijk, dubbelzinnig.

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#2 Immad



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Posted 25 June 2009 - 09:13 AM

Interessant, dit wist ik niet. Als dit inderdaad zo blijkt te zijn, dan stop ik volledig met mijn wekelijkse sigaartje als de resultaten significant zijn. Tot die tijd maar flink minderen.

#3 Dreadmanneke


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Posted 08 July 2009 - 01:19 PM

Wat ik me altijd afvraag is wat voor tabak ze gebruiken bij onderzoek? Gebruiken ze standaard cigaretten, die wij ook roken, of gebruiken ze pure onbewerkte tabak? Lijkt me namelijk dat al die toevoegingen een groot verschil maken. Ik zeg dit door een opmerking van Jeremy Narby in the cosmic serpent dat in de Amazone de tabaquiros vaak de dorpsoudsten zijn, en ze daar ook hele andere tabak roken dan wij, en dat dat mogelijk enorm verschil uitmaakt in schadelijkheid.

Wat is NNK voor stof, behalve dat het een procarinogeen is?

Ze noemen de hoeveelheden NNK in tabak, maar wat voor hoeveelheden hebben ze gebruikt om de neuroinflammatorische effecten teweeg te brengen in de petrischaaltjes?

Hoe sterk zijn de verbanden? Ik vind dergelijk taalgebruik altijd nogal suggestief: "suggests a direct link", "believe it may cause neuroinflamation", "this research suggests damage is not confined only to smoking".
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