As a general rule, Erowid neither recommends nor discourages the use of any psychoactive, however, in the case of tropane alkaloid-containing Solanaceae plants, we think it is important to note that an overwhelming majority of those who describe to us their use of Datura (and to a lesser extent, Belladonna, Brugmansia and Brunfelsia) find their experiences extremely mentally and physically unpleasant and not infrequently physically dangerous.
There is no way to guess a reasonable dose, because potency of the plant material itself and appropriate dose for an individual appear to vary so much. The question of what "reasonable" means for something that so often leads to such ridiculously negative effects is hard to say.
As an admixture plant in some traditional ayahuasca brews, smoking blends, or other preparations, parts of these plants are generally used in very low doses. Because of the serious adverse consequences associated with tropane alkaloids (scopolamine, atropine, hyoscyamine) intoxication and the wide variation in doses used, we are unwilling to even speculate about specific dosages for the leaves, flowers, and seeds of these plants.
If you are considering ingesting Datura-group plants, please read extensively from the collected experience reports and never take them without a reliable, sober sitter who understands the likely health issues and who can stop you from walking in front of traffic. Please note that fatalities from ingesting Datura do occur and hospitalizations seem to be quite common, in spite of the relatively low rates of psychoactive use of these plants.
http://www.erowid.org/plants/datura/
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