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Xenon gasduur en zeldzaam


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#1 Videlic

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Posted 25 January 2021 - 08:10 PM

Ik stuitte op deze video van Hamilton Morris, die Xenon gas probeert.

 

Dit schijnt nogal een zelfdzaam en duur dissociatief gas te zijn, vergelijkbaar met lachgas, voor medische toepassingen en ook lampen.

 

Volgens mij was hier nog geen topic over. Hier is de uncut video:

 

/https://www.youtube....ture=emb_title/

 

(embed werkt niet)

 

"Ongelofelijk en meer euforisch dan lachgas", is de conclusie.


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#2 Phlogiston

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Posted 26 January 2021 - 03:22 PM

Ik dacht altijd dat xenon werkt via oxygen deprivation, maar wikipedia heeft me zojuist geleerd dat dit niet het geval is. Nu wil ik het ook proberen.


"Xenon interacts with many different receptors and ion channels, and like many theoretically multi-modal inhalation anesthetics, these interactions are likely complementary. Xenon is a high-affinity glycine-site NMDA receptor antagonist. However, xenon is different from certain other NMDA receptor antagonists in that it is not neurotoxic and it inhibits the neurotoxicity of ketamine and nitrous oxide, while actually producing neuroprotective effects. Unlike ketamine and nitrous oxide, xenon does not stimulate a dopamine efflux in the nucleus accumbens.

Like nitrous oxide and cyclopropane, xenon activates the two-pore domain potassium channel TREK-1. A related channel TASK-3 also implicated in the actions of inhalation anesthetics is insensitive to xenon. Xenon inhibits nicotinic acetylcholine α4β2 receptors which contribute to spinally mediated analgesia. Xenon is an effective inhibitor of plasma membrane Ca2+ ATPase. Xenon inhibits Ca2+ ATPase by binding to a hydrophobic pore within the enzyme and preventing the enzyme from assuming active conformations.

Xenon is a competitive inhibitor of the serotonin 5-HT3 receptor. While neither anesthetic nor antinociceptive, this reduces anesthesia-emergent nausea and vomiting."

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