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Toxic by design? Formation of thermal degradants and cyanide from carboxamide-type synthetic cannabinoids during exposure to high temperaturesForensic Toxicol (2019) 37: 17 - 10.1007/s11419-018-0430-0

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#1 Phlogiston

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Posted 31 August 2019 - 06:28 PM

Bron: https://link.springe...1419-018-0430-0

 

Toxic by design? Formation of thermal degradants and cyanide from carboxamide-type synthetic cannabinoids CUMYL-PICA, 5F-CUMYL-PICA, AMB-FUBINACA, MDMB-FUBINACA, NNEI, and MN-18 during exposure to high temperatures
  Abstract
Purpose

The use of novel synthetic cannabinoids as intoxicants continues in spite of associated health risks. These compounds are typically smoked or vaporized, but many synthetic cannabinoids contain thermally labile chemical moieties. This study investigated the thermal stability of six carboxamide-type synthetic cannabinoids (CUMYL-PICA, 5F-CUMYL-PICA, AMB-FUBINACA, MDMB-FUBINACA, NNEI, and MN-18) in order to characterise potential user exposure to thermolysis products.

Methods

Compounds were heated sequentially to 200, 400, 600 and 800 °C using a thermolysis probe, and the resultant thermolysis products were analysed via gas chromatography–mass spectrometry. A secondary analysis quantified thermolytically generated cyanide via liquid chromatography–tandem mass spectrometry.

Results

All six synthetic cannabinoids underwent thermal degradation when heated above 400 °C, and released a variety of potentially toxic products, including toluene, naphthalene, and 1-naphthalamine. Compound-specific degradants were tentatively identified together with general degradative pathways for carboxamide-type synthetic cannabinoids, which proceed via indole- or indazole-amide formation and subsequent dehydration to an indole- or indazole-carbonitrile. These degradative pathways culminated in the thermolytic liberation of cyanide, in amounts up to 27 µg per mg of starting material.

Conclusions

People who smoke carboxamide-type synthetic cannabinoids are likely to be exposed to a range of potentially toxic thermal degradants, including cyanide. These degradants could have significant health impacts in human users.

 

 

 

Nog meer redenen om van deze stofjes weg te blijven


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#2 Immad

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Posted 02 September 2019 - 11:07 AM

Inderdaad. Niet dat ik ooit synthetische cannabinoiden gebruikt heb of dat wil doen, maar zijn deze stoffen te verdampen bij <200 graden en kun je zo dit probleem vermijden?



#3 Phlogiston

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Posted 03 September 2019 - 05:03 PM

In het artikel staat dat niet alle stoffen verdampen bij 200C. Welke dit waren zie ik niet.

Maar met een vaporiser die op 200C kan worde afgesteld zou inderdaad veel van deze schadelijke degradatie producten niet vormen. Wat overigens niks zegt over de mogelijke schadelijke van de stofjes zelf.

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