Structuur van MEAI:
Normaal gesproken zou ik een compound als deze weinig aandacht hebben gegeven, maar dit is blijkbaar een van de compounds die David Nutt aan het pushen is als alcohol vervanger. Als eerst dus wikipedia pagina opzoeken, om te zien wat er over bekend is, maar gek genoeg linkt "MEAI" door naar de pagina van Nutt, waar er het volgende over dit middelen geschreven wordt:
Alcosynth
Starting in around 2014 Nutt said he intends to bring to market a recreational drug which has same effect as alcohol but does less physical harm; a safer replacement. He calls it "alcosynth", but does not disclose the exact chemical(s). Early tests used a benzodiazepine derivative, but later candidates do not. Also a drug he calls "chaperone" that he said attenuates the effects of alcohol.[23][24]
According to an article by Michael Slezak in the New Scientist in December 2014, the "chaperone" drug was 5-methoxy-2-aminoindane (MEAI), which was "created" by a recreational drug chemist who goes by "Dr. Z"[25], who filed a patent[26] application on the drug in November 2014 and, when the article was published, was going to donate the patent application to Nutt's nonprofit organization.[27]
As of October 2016 none of these compounds were available to consumers, their long health effects were not known, and there was no published research about them.[28] A peer reviewed paper about MEAI was published in March 2017 by Nutt in the journal Toxicology and Applied Pharmacology,[29] followed by another in February 2018 which detailed pharmacokinetics, pharmacodynamics and metabolism of MEAI.[30].
In 2018 a company in the United States began offering an MEAI-based drink called "Pace".[31]
We hadden al een topic/artikel over Alcosynth: Alcosynth - alcohol alternatief, maar daar staat verder niks interessant in over dit middel.
Verder vond ik deze twee relevante papers over MEAI;
Toxicological evaluation of 5-methoxy-2-aminoindane (MEAI): Binge mitigating agent in development
Pharmacokinetic and pharmacodynamic evaluation of 5-methoxy-2-aminoindane (MEAI): A new binge-mitigating agent
Een quote uit het eerste artikel:
5-Methoxy-2-aminoindane (MEAI or Chaperon) is a psychoactive compound of the aminoindane class with a mechanism of action de- scribed by one patent as being possibly mediated by binding to the do- pamine D3 receptor (Haadsma-Svensson et al., 1994). In recent years MEAI has been recreationally used by many people, mainly in the UK, who report a mild euphoric, alcohol-like tipsy experience ( Nutt, 2013; Slezak, 2014 ). Typically recreational users ingest orally MEAI at doses of up to 1 2 mg/kgbodyweightin a session and report an onset of effect of up to 4 h with reduced desire to consume alcoholic beverages. This observation has led us to hypothesize that MEAI could potentially be used as a binge mitigation agent, that could impart a feeling of satisfac- tion, satiety or contentedness and regulate or even discourage binge drinking.
Een screenshot uit het tweede artikel:
Tot dus ver heb ik nog niks gezien wat mij overtuigd van een alcohol-achtig effect, of zelfs iets dat alcohol consumptie remt. Daarom ook dit topic in het 'Uppers' subfora geplaatst.
Ben heel benieuwd of iemand ervaring me dit middel heeft en kan bevestigen dat het inderdaad een "tipsy" effect heeft en dus meer interessant is dan weer een andere (shitty) stimulant?
