Jump to content


Photo

Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogensEuropean Neuropsychopharmacology - 10.1016/j.euroneuro.2016.05.001

Tryptamines

  • Please log in to reply
No replies to this topic

#1 Phlogiston

Phlogiston

    poelitie

  • Admin
  • PipPipPipPipPipPip
  • 6,261 posts

Posted 02 July 2018 - 08:17 PM

Bron: https://www.european...0042-6/abstract

 

Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens
 

Abstract

The present study investigated interactions between the novel psychoactive tryptamines DiPT, 4-OH-DiPT, 4-OH-MET, 5-MeO-AMT, and 5-MeO-MiPT at monoamine receptors and transporters compared with the classic hallucinogens lysergic acid diethylamide (LSD), psilocin, N,N-dimethyltryptamine (DMT), and mescaline. We investigated binding affinities at human monoamine receptors and determined functional serotonin (5-hydroxytryptamine [5-HT]) 5-HT2A and 5-HT2B receptor activation. Binding at and the inhibition of human monoamine uptake transporters and transporter-mediated monoamine release were also determined. All of the novel tryptamines interacted with 5-HT2A receptors and were partial or full 5-HT2A agonists. Binding affinity to the 5-HT2A receptor was lower for all of the tryptamines, including psilocin and DMT, compared with LSD and correlated with the reported psychoactive doses in humans. Several tryptamines, including psilocin, DMT, DiPT, 4-OH-DiPT, and 4-OH-MET, interacted with the serotonin transporter and partially the norepinephrine transporter, similar to 3,4-methylenedioxymethamphetamine but in contrast to LSD and mescaline. LSD but not the tryptamines interacted with adrenergic and dopaminergic receptors. In conclusion, the receptor interaction profiles of the tryptamines predict hallucinogenic effects that are similar to classic serotonergic hallucinogens but also MDMA-like psychoactive properties.

 


Drugs against War



... R.I.P. Toasted ...





0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users