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A unique natural selective kappa-opioid receptor agonist, salvinorin A, and its roles in human therapeuticsPhytochemistry, May 2017

Review Salvia Salvinorin A

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#1 Phlogiston

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Posted 21 November 2017 - 10:16 AM

Bron: http://www.sciencedi...300420?via=ihub

 

A unique natural selective kappa-opioid receptor agonist, salvinorin A, and its roles in human therapeutics
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Highlights

• Salvinorin A is a main component of S. divinorum and is responsible for its hallucinogenic effects. 
•Salvinorin A is the most potent natural hallucinogen and is a selective kappa-opioid receptor agonist.

• Salvinorin A has various biological effects.

• Salvinorin A could be used as a therapeutic agent in various disorders and/or pathologies.

 

Abstract

Until the mid-60s, only the Mazatecs, an indigenous group from Oaxaca, Mexico, used Salvia Divinorum (S. divinorum) due to its hallucinogen properties.

Later it was found that the hallucinogen effects of this plant were caused by the presence of a neoclerodane diterpene Salvinorin A (salvinorin A), which is a highly selective agonist of kappa-opioid receptor (KOR) that cause more intense hallucinations than the common hallucinogens as lysergic acid, mushrooms, ecstasy and others. In fact, smoking of only 200–500 μg of S. divinorum leaves is enough to produce these effects thus making it the most potent natural occurring hallucinogen known.

Due to its legal status in various countries, this compound has gained a worldwide popularity as a drug of abuse with an easy access through smartshops and internet.

Furthermore, salvinorin A gathered an increased interest in the scientific community thanks to its unique structure and properties, and various studies demonstrated that salvinorin A has antinociceptive, antidepressant, in some circumstances pro-depressant and anti-addictive effects that have yielded potential new avenues for research underlying salvinorin A and its semi-synthetic analogs as therapeutic agents.

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#2 Immad

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Posted 25 November 2017 - 05:09 PM

200 - 500 ug Salviabladeren bevatten wel heel weinig Salvinorin A ;)



#3 Phlogiston

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Posted 26 November 2017 - 07:13 AM

Overduidelijk dat ze Salvinorin A bedoelen.

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#4 Immad

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Posted 26 November 2017 - 02:58 PM

Uiteraard, maar het verbaast me dat een paper, waar toch veel werk in zit, zulke slordigheden bevat.



#5 Phlogiston

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Posted 26 November 2017 - 04:27 PM

Ben het met je eens dat het een slordige fout is, maar misschien moet je ook niet te veel verwachten van deze journal, niet het meest impactvolle.. ;)

Verder vond ik het overigens wel een okay review, vandaar dat ik het hier heb gepost. :)


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